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The vermiform appendix was a part of the large intestine of Humans. Largely useless, most people disregarded its existence.

In 2264, Elias Sandoval's appendix grew back when he was exposed to the Omicron spores, the organ having previously been removed. (TOS: "This Side of Paradise")

In 2267, after Spock, regained his sight, having previously been blinded, he compared his Vulcan inner eyelid which had instinctively protected him to the Human appendix, in that both were generally ignored. (TOS: "Operation -- Annihilate!")

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