Antwerp was an Earth city in the northeastern part of Belgium.

In 2372, Antwerp was the location of a high level diplomatic conference held between the United Federation of Planets and the Romulan Star Empire. It was bombed by a Changeling infiltrator, killing 27 people, including the Tholian observer. The attack signified a Dominion presence on Earth. (DS9: "Homefront")

It is unclear whether or not Antwerp hosted a specific Federation office, such as Paris, San Francisco, and Lisbon did.

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