An antacid was a form of medication that helped alleviate acute functional dyspepsia (heartburn).

When Neelix made up Rodeo Red's Red-Hot, Rootin'-Tootin' Chili in 2374, several crewmembers suffered from heartburn, thus requiring Tom Paris to replicate an antacid for them. (VOY: "Message in a Bottle")

In the writers' second draft script of ENT: "Breaking the Ice", it was established that, aboard Enterprise NX-01, Doctor Phlox kept antacids, which were described in the stage directions as "pink tablets", in a wall dispenser in sickbay. Despite initially being unsure where they were stored, Captain Archer retrieved "a couple" of these for himself after hosting a meal with Vulcan Captain Vanik. Although Commander Trip Tucker asked Archer if the antacids were required because Vanik had annoyed him, Archer replied that he was suffering indigestion from having eaten meatballs and Vulcan food, the latter of which had been specially prepared for Vanik (though he hadn't eaten any of it). Tucker reacted as if he was skeptical of this explanation and told Archer, "I hope the shelf-life on those antacids has expired." An amused Archer then popped his antacids while exiting sickbay.

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