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In 2372, the USS Voyager came across Pralor Automated Unit 3947 damaged in space. Lieutenant B'Elanna Torres connected a series of modified anodyne relays to its chromodynamic power module, which allowed her to infuse warp plasma into its energy matrix. Torres later told 3947, that he would have to remodulate the relays periodically. (VOY: "Prototype")
In 2373, there was a minor malfunction aboard Voyager. Tom Paris bet that the anodyne relay was responsible, while B'Elanna Torres said it was a plasma conduit. Paris won, and had Torres join him in the Klingon martial arts program. (VOY: "Distant Origin")
That same year, while traveling with Odo aboard a runabout, Quark complained about a buzzing noise coming from under a panel. Odo suggested that it was a faulty anodyne circuit, to which Quark replied that faulty anodyne circuits make a hissing sound. (DS9: "The Ascent")