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Annunciation was the first painting done by the Human Leonardo da Vinci in the late 15th century in Europe on Earth. The painting depicted the angel Gabriel telling Mary that she would conceive Jesus Christ, the son of God.

The painting was also found among the relics in Kathryn Janeway's da Vinci holodeck program. (VOY: "Scorpion", "Scientific Method", "Concerning Flight", "The Raven")

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