In 2364 she accompanied her husband, who suffered from the Iverson's Disease aboard the USS Enterprise-D to be with him on his mission as negotiator on Mordan IV. She was surprised by the beauty and size of the guest quarters aboard the Enterprise-D and told her husband that they would never been apart during his time on starships when they have had quarters this size.
Jameson was shocked when she learned that her husband injected himself with de-aging drugs from Cerberus II and was in pain seeing him suffer from this drug and also getting younger every hour. Jamison originally planned to test the drug and then use it together with his wife but when he learned that Karnas asked for him to negotiate he used both dosages. Anne Jameson got angry about her husband and noted that her opinion was never in demand. She would never use this drug.
She was by his side when he died on Mordan IV as a result of the drug he had taken to reverse the aging process. She requested that her husband Mark be buried on Mordan IV, which was accepted by Karnas. (TNG: "Too Short a Season")