Anesthesia gas was an anesthetic drug available – in gaseous form – during the 22nd century.

In 2151, Enterprise NX-01 was attacked by a Ferengi vessel that flooded Enterprise with anesthesia gas. This was an attempt to steal all the items of value and the females on board, as the Ferengi starship's crew intended to sell them for a profit. (ENT: "Acquisition")

By the 23rd century, anesthesia gas was available to Constitution-class starships in the United Federation of Planets. In 2267, Commander Spock and Captain James T. Kirk flooded almost all decks on the USS Enterprise with anesthesia gas to retake the ship from Khan Noonien Singh and a group of Augments led by him. (TOS: "Space Seed")

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