They were considered to have a strong presence in a certain sanctuary. There, while on shore leave in 2373, Kes was severely injured by a neuroleptic shock she received upon inadvertently entering a shrine. Though sympathetic, the Nechani magistrate believed that she had been punished by the Spirits and was beyond help.
Based on the old story of King Nevad, who appealed to the Spirits directly to spare his son's life after a similar accident, Captain Kathryn Janeway participated in a purification ritual to commune with the Spirits to save Kes. During the ritual, she was informed that she should take Kes back into the shrine, and trust the Spirits to return her soul. (VOY: "Sacred Ground")