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Amputation was a surgical procedure whereby a patient's appendages were removed.

In 2152, following his impalement by a Romulan mine, Malcolm Reed joked that he might consider allowing his leg to be amputated, except he thought that if Chef got hold of the severed limb, he would serve "Roast Reed" next Sunday. (ENT: "Minefield")

A deleted scene in "Broken Bow" had Reed jokingly tell Hoshi Sato, who believed she suffered from frostbite, that Dr. Phlox might have to amputate.

In 2369, William T. Riker's arm was amputated and then surgically re-attached by Solanogen-based lifeforms that were experimenting on crew members of USS Enterprise-D. (TNG: "Schisms")

In 2375, a severe injury to Nog's left leg necessitated amputation. Nog had been shot by Jem'Hadar on AR-558. (DS9: "The Siege of AR-558")

In 2376, Lieutenant Maxwell Burke joked with Seven of Nine about needing amputation for her minor injuries (first degree phaser burns and minor lacerations), which Seven did not appreciate. (VOY: "Equinox, Part II")

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