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Amputation was a surgical procedure whereby a patient's appendages were removed.

In 2152, following his impalement by a Romulan mine, Malcolm Reed joked that he might consider allowing his leg to be amputated, except he thought that if Chef got hold of the severed limb, he would serve "Roast Reed" next sunday. (ENT: "Minefield")

A deleted scene in "Broken Bow" has Reed examining the hands of a frostbitten Hoshi Sato, saying that Dr. Phlox might have to amputate.

In 2369, William T. Riker's arm was amputated and then surgically re-attached by Solanogen-based lifeforms that were experimenting on crew members of USS Enterprise-D. (TNG: "Schisms")

In 2375, a severe injury to Nog's left leg necessitated amputation. (DS9: "The Siege of AR-558")

In 2376, Lieutenant Maxwell Burke joked with Seven of Nine about needing amputation for her minor injuries (first degree phaser burns and minor lacerations), which Seven did not appreciate. (VOY: "Equinox, Part II")

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