The Amazon River was an immense river found in the Amazon region of South America on Earth.

In 2152, Jonathan Archer referenced the Amazon River when he attempted to teach Trip Tucker how to play the game Geography. Archer explained the game by giving the example: "You say Amazon River, which ends in an "R", and then I say Rhode Island." (ENT: "Desert Crossing")

In a scene deleted from "Fight or Flight", Ensign Travis Mayweather also referenced the Amazon River in a similar game he played with Archer. Mayweather and Archer used the same locations as Tucker and Archer later.

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