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Alpha 441 was the original target of the Cardassian missile Dreadnought, launched in 2370. The missile was able to reach the target, but then failed to explode due to an obsolete kinetic detonator used in the warhead. Afterward B'Elanna Torres reprogrammed the missile to destroy the Cardassian fuel depot on Aschelan V. (VOY: "Dreadnought")