- After Geordi LaForge was given the impossible task, in 2366, of adapting the USS Enterprise-D transporters to function through hyperonic radiation, after several attempts to make the proper configuration, he finally informed Captain Jean-Luc Picard, that they could modify the transporters but that it would take until this year for a research team of a hundred to complete the task. (TNG: "The Ensigns of Command")
- Min Riker, William T. Riker's wife in the future created for him by Barash in TNG: "Future Imperfect" was said to have occurred in 2381.
- In an alternate timeline, Starfleet Command has the deep space vessel assigned to search for the missing USS Voyager give its search six years after it crash landed on an unidentified planet in the Takara sector. (VOY: "Timeless")
- In another alternate timeline, Seven of Nine dies aboard Voyager after being injured on an away mission. (VOY: "Endgame")
- The events of Star Trek: Destiny take place in this year.