- 2381: According to Geordi La Forge, the Federation will be able to have transporters that are able to successfully work on Tau Cygna V if they started in 2366. (TNG: "The Ensigns of Command")
- 2385: According to Section 31 estimates, the Klingon Empire will have finally recovered from their losses during the Dominion War. (DS9: "Inter Arma Enim Silent Leges")
- 2387: Romulus is destroyed by an unusually powerful supernova; Spock stops the supernova from growing, but is flung in time to an alternate 2258. (Star Trek)
Alternate timeline events
- The following event took place in an alternate timeline in which the USS Voyager was destroyed while navigating the quantum slipstream in 2375. (VOY: "Timeless")
- 2380: Starfleet officially abandons the search for Voyager.
- The following event takes place in an alternate timeline when the USS Voyager did not return to Earth in 2378. (VOY: "Endgame")
- 2381: After she receives fatal injuries on an away mission, Seven of Nine dies on Voyager, in the arms of her husband, Chakotay.
- The following events took place in an alternate timeline where Captain Benjamin Sisko was temporally displaced. (DS9: "The Visitor")
- 2382: Jake Sisko marries Korena.
- 2389: Benjamin Sisko briefly appears in Jake's house in New Orleans.
- In "The Dogs of War", Benjamin Sisko predicted that if the Federation Alliance did not launch an assault against the Dominion in late 2375, they would re-arm themselves and launch an offensive in the early 2380s.
- 2380: The post-"Endgame" portions of the FPS game Star Trek: Elite Force II take part in this year.
- The last climactic missions of Star Trek: Legacy take place in 2380 also.
- Events described in Taking Wing:
- Events described in Resistance:
- Events described in Before Dishonor:
- Kathryn Janeway is assimilated by the Borg, made the new Borg Queen and killed after this, according to official record; her ultimate fate remains unknown, it is hinted that she has become a companion of Lady Q.
- The Borg reach their next step of evolution - instead of assimilating, they now "absorb" whole starships, with the ships becoming part of the absorbing Borg cube and the crew being assimilated.
- Events described in Star Trek: Destiny:
- 2381 The Borg have declared war on the Federation and its allies with the goal of eradication over assimilation. By the end of the war, major colonies have destroyed, the core worlds nearly destroyed and more, but the Borg are no more either. They were reunited with an ancient civilization.
- Events described in Unworthy:
- Countdown: "Number One" begins on stardate 64333.4, in 2387.
- Beginning of the path to 2409, events leading up to Star Trek Online.
- In the game Star Trek: Armada, the USS Premonition is supposedly built in an alternate timeline where the Borg have control of most of the Alpha Quadrant. Due to the Premonition's temporal drive, it went back in time to 2376 to stop the first Borg attack on Starbase 612. It returned to the future after a successful effort in defeating the Borg. (Star Trek: Armada)