- Dr. Beverly Crusher leaves the USS Enterprise-D to become head of Starfleet Medical. She is replaced by Dr. Katherine Pulaski. Geordi La Forge is promoted to full lieutenant and made the Enterprise chief engineer. Worf is permanently made Enterprise security chief. (TNG: "The Child")
- Events aboard the USS Lantree, prior to stardate 42494.8:
- Eight weeks before - The 26 crew members of the supply ship are examined by a medical staff. They are judged as fit for duty. The USS Lantree begins its tour of duty in Sector Gamma 7.
- Five days before - The First Officer is treated for Thelusian flu.
- Three days before - The Lantree visits the Darwin Genetic Research Station on Gagarin IV.
- Stardate 42493.1 - Captain L. Isao Telaka records his last log. (TNG: "Unnatural Selection")
- One week before stardate 42494.8, Sara Kingsley celebrates her 35th birthday on Gagarin IV. (TNG: "Unnatural Selection")
- Commander William T. Riker becomes the first Starfleet officer to serve on a Klingon vessel when he participates in the Officer Exchange Program. (TNG: "A Matter Of Honor")
- Captain Jean-Luc Picard helps to define the rights of artificial life after Commander Bruce Maddox attempts to disassemble Data in order to construct more androids like him. Data is granted the full rights appropriate to all sentient lifeforms. (TNG: "The Measure Of A Man")
- Riker is offered command of the USS Aries, but declines the offer to remain with the Enterprise. (TNG: "The Icarus Factor")
- The United Federation of Planets makes First Contact with the Borg after Q hurls the Enterprise-D 7,000 light years to System J-25. (TNG: "Q Who")
- Starfleet initiates a series of tactical training and development programs designed to ready the fleet for the Borg invasion. (TNG: "Peak Performance", "The Best of Both Worlds")
- Guinan comes aboard the Enterprise-D at Captain Picard's personal request. She takes the position of bartender in Ten Forward. (TNG: "The Best of Both Worlds")
- The USS Yamato is destroyed after discovering the homeworld of the ancient Iconians. (TNG: "Contagion")
- A 328-year-old mystery is solved when the Enterprise crew finds the remains of Colonel Stephen G. Richey, a NASA astronaut whose spacecraft, Charybdis, disappeared in 2037. (TNG: "The Royale")
- Dukat brings Odo to Terok Nor to investigate the murder of Vaatrik, a Bajoran chemist. Odo meets Kira Nerys and Quark for the first time, but does not solve the case. (DS9: "Necessary Evil")
- Morn, Hain, Larell, Krit, and Nahsk take part in the Lissepian Mother's Day Heist on Lissepia. (DS9: "Who Mourns for Morn?")
- A Talaxian ship with a crew of 23 is taken prisoner by the Vidiians and sent to Avery III. (VOY: "Faces")
- A month before stardate 42823.2, Starbase 73 receives a distress call from the Earth colony of Bringloid V. (TNG: "Up The Long Ladder")
- The USS Enterprise-D reunites the descendants of the colony ship SS Mariposa on the planet Mariposa. (TNG: "Up The Long Ladder")
- In a winter flood on Mintaka III, six Mintakans drown. Counted among the dead, there are four children and two adults. One of the adults is the wife of Liko and mother to their daughter Oji. (TNG: "Who Watches The Watchers")
- Tuvok and Kathryn Janeway begin to form a bond as Janeway learns to rely on Tuvok's advice. (VOY: "Revulsion")
- In a two hour lecture course in astral physics, Wesley Crusher first learns of the Elway Theorem. (TNG: "The High Ground")
- Chu'lak begins to serve aboard the USS Grissom. (DS9: "Field of Fire")
- Benjamin Sisko and Solok meet for what will be the last time in the next ten years. (DS9: "Take Me Out to the Holosuite")
- Calvin Hutchinson mets Beverly Crusher for the last time, before they are see each again four years later on Arkaria. (TNG: "Starship Mine")
- "The Child"
- "Where Silence Has Lease"
- "Elementary, Dear Data"
- "The Outrageous Okona"
- "The Schizoid Man"
- "Loud As A Whisper"
- "Unnatural Selection"
- "A Matter Of Honor"
- "The Measure Of A Man"
- "The Dauphin"
- "The Royale"
- "Time Squared"
- "The Icarus Factor"
- "Pen Pals"
- "Q Who"
- "Samaritan Snare"
- "Up The Long Ladder"
- "The Emissary"
- "Peak Performance"
- "Shades of Gray"
- "Necessary Evil" (in part)