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- Lenore Karidian is born. (TOS: "The Conscience of the King")
- The first of many thousands of lives lost in the Eminiar-Vendikar War in a star system of Star Cluster NGC 321 is recorded by the United Federation of Planets. After suffering for nearly two decades this mounting loss of life, the Federation would seek permission from the planet Eminiar VII for the construction of a treaty port in their star system in 2267. (TOS: "A Taste of Armageddon")
- As he claims, this is the last time before 2267, that Montgomery Scott sees a PXK pergium reactor. (TOS: "The Devil in the Dark")