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- A mining colony is established on the planet Janus VI, which soon becomes the Federation's key source of pergium and other rare ores. Unknown to the colonists is that the planet is actually the homeworld of the Horta species. (TOS: "The Devil in the Dark")
- The Zeon people establish a colony on the nearby planet Ekos. A half a century later, this colony would be wiped out virtually overnight by a genocide purge ordered by John Gill who was then under the influence of his deputy Melakon. (TOS: "Patterns of Force")