- Humanity unofficially makes first contact with the Klingon Empire when Klaang crash-lands in Broken Bow, Oklahoma. (ENT: "Broken Bow")
- Earth Starfleet launches Enterprise NX-01, its first starship to use the warp five engine, opening up a new age of exploration for Earth. Enterprise also begins Humanity's involvement in the Temporal Cold War with the first encounter with the Suliban Cabal. (ENT: "Broken Bow")
- Other Earth first contacts this year include the Akaalis, the Axanar, the Coridans, the Eska, the Kantare, the Malurians, the Menk, the Valakians, and the Xyrillians. (ENT Season 1)
- The episodes "Silent Enemy" and "Cold Front" are placed in reverse airing order in this timeline. The reason for this is because "Silent Enemy" is explicitly said to occur on September 1, whereas "Cold Front" is said to happen four months, four weeks, and six days since Enterprise left Earth (April 13), which puts it on September 9.