- Khan Noonien Singh rises to power in the Middle East and Asia. (TOS: "Space Seed")
- The Eugenics Wars begin on Earth. (TOS: "Space Seed")
- The book called Chicago Mobs of the Twenties is published in New York, on Earth. (TOS: "A Piece of the Action")
- The novel series Star Trek: The Eugenics Wars depicts the events around Khan's rise to power and the ensuing wars during the 1990s.
- According to the Star Trek Encyclopedia (3rd ed., p. 23}, Dr. Isaac Asimov dies.