Following the Great Depression and the World War II on Earth, the Brush Wars and the Earth Cold War rise to dangerous levels. The fear instilled in many Human youths in the 1950s and the tragic deaths of hopeful figures like John F. Kennedy lead them to seeking alternative lifestyles such as the rock 'n roll movement and the hippie counterculture. The Civil Rights Movement begins, as well as several student protest organizations, including the Free Speech Movement at Berkeley, California.
In the field of art and entertainment, the films The Alamo and Rosemary's Baby are released. Mission: Impossible is a popular television program during this decade. Performers include the Berman's Rainbow Dreamers, Steppenwolf, and Jimi Hendrix. The Woodstock Music and Art Festival is a milestone event of the hippie era.
The Human "space race" reaches its peak. Along with the launch of the Ranger and Apollo spacecraft, Humanity makes the first steps on another world when Neil Armstrong walks on Luna at the end of the decade. The crash and salvaging of a "UFO" triggers an advancement in technology, with the development of the first isograted circuit.
- An attempt at viral genetic engineering, the life prolongation complex, annihilates all life except prepubescent children on a distant planet that is a physical copy of Earth. The complex halts aging in these children, who survive for at least three hundred more years, until the USS Enterprise discovers them in 2266. (TOS: "Miri")
- The Earth Cold War rises to dangerous levels of hostilities, viewed by several major powers as a possible catalyst for World War III. To keep a political edge, many nations fund extensive espionage programs. Centuries later, the Deep Space 9 holosuite holoprograms "Julian Bashir, Secret Agent" and "Bashir 62" are set during this period.
- The city of Las Vegas will see its "golden age" in the 1960s. Centuries later, the holoprogram "Vic's Las Vegas Lounge" is set during this decade.