145th and Lennox was the location of an intersection of two streets in Harlem, a district in New York City.
On one night in 1953, as Benny Russell was walking home to his apartment after exiting the subway station, he had a chance encounter with The Preacher near this intersection. (DS9: "Far Beyond the Stars")
This location was not mentioned in the episode, but rather comes from the script, which also misspelled the name "Lenox".